Mathematical modeling of renal hemodynamics in physiology and pathophysiology.


Journal Article

In addition to the excretion of metabolic waste and toxin, the kidney plays an indispensable role in regulating the balance of water, electrolyte, acid-base, and blood pressure. For the kidney to maintain proper functions, hemodynamic control is crucial. In this review, we describe representative mathematical models that have been developed to better understand the kidney's autoregulatory processes. We consider mathematical models that simulate glomerular filtration, and renal blood flow regulation by means of the myogenic response and tubuloglomerular feedback. We discuss the extent to which these modeling efforts have expanded the understanding of renal functions in health and disease.

Full Text

Duke Authors

Cited Authors

  • Sgouralis, I; Layton, AT

Published Date

  • June 2015

Published In

Volume / Issue

  • 264 /

Start / End Page

  • 8 - 20

PubMed ID

  • 25765886

Pubmed Central ID

  • 25765886

Electronic International Standard Serial Number (EISSN)

  • 1879-3134

International Standard Serial Number (ISSN)

  • 0025-5564

Digital Object Identifier (DOI)

  • 10.1016/j.mbs.2015.02.016


  • eng