Na+ channel function, regulation, structure, trafficking and sequestration.

Journal Article (Journal Article;Review)

This paper is the second of a series of three reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation-contraction coupling and arrhythmias: Na(+) channel and Na(+) transport. The goal of the symposium was to bring together experts in the field to discuss points of consensus and controversy on the topic of sodium in the heart. The present review focuses on Na(+) channel function and regulation, Na(+) channel structure and function, and Na(+) channel trafficking, sequestration and complexing.

Full Text

Duke Authors

Cited Authors

  • Chen-Izu, Y; Shaw, RM; Pitt, GS; Yarov-Yarovoy, V; Sack, JT; Abriel, H; Aldrich, RW; Belardinelli, L; Cannell, MB; Catterall, WA; Chazin, WJ; Chiamvimonvat, N; Deschenes, I; Grandi, E; Hund, TJ; Izu, LT; Maier, LS; Maltsev, VA; Marionneau, C; Mohler, PJ; Rajamani, S; Rasmusson, RL; Sobie, EA; Clancy, CE; Bers, DM

Published Date

  • March 15, 2015

Published In

Volume / Issue

  • 593 / 6

Start / End Page

  • 1347 - 1360

PubMed ID

  • 25772290

Pubmed Central ID

  • PMC4376415

Electronic International Standard Serial Number (EISSN)

  • 1469-7793

Digital Object Identifier (DOI)

  • 10.1113/jphysiol.2014.281428


  • eng

Conference Location

  • England