Effect of Repetitive Transcranial Magnetic Stimulation on fMRI Resting-State Connectivity in Multiple System Atrophy.


Journal Article

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique that has been used to treat neurological and psychiatric conditions. Although results of rTMS intervention are promising, so far, little is known about the rTMS effect on brain functional networks in clinical populations. In this study, we used a whole-brain connectivity analysis of resting-state functional magnetic resonance imaging data to uncover changes in functional connectivity following rTMS intervention and their association with motor symptoms in patients with multiple system atrophy (MSA). Patients were randomized to active rTMS or sham rTMS groups and completed a 10-session 5-Hz rTMS treatment over the left primary motor area. The results showed significant rTMS-related changes in motor symptoms and functional connectivity. Specifically, (1) significant improvement of motor symptoms was observed in the active rTMS group, but not in the sham rTMS group; and (2) several functional links involving the default mode, cerebellar, and limbic networks exhibited positive changes in functional connectivity in the active rTMS group. Moreover, the positive changes in functional connectivity were associated with improvement in motor symptoms for the active rTMS group. The present findings suggest that rTMS may improve motor symptoms by modulating functional links connecting to the default mode, cerebellar, and limbic networks, inferring a future therapeutic candidate for patients with MSA.

Full Text

Duke Authors

Cited Authors

  • Chou, Y-H; You, H; Wang, H; Zhao, Y-P; Hou, B; Chen, N-K; Feng, F

Published Date

  • September 2015

Published In

Volume / Issue

  • 5 / 7

Start / End Page

  • 451 - 459

PubMed ID

  • 25786196

Pubmed Central ID

  • 25786196

Electronic International Standard Serial Number (EISSN)

  • 2158-0022

Digital Object Identifier (DOI)

  • 10.1089/brain.2014.0325


  • eng

Conference Location

  • United States