T cell metabolic fitness in antitumor immunity.


Journal Article (Review)

T cell metabolism has a central role in supporting and shaping immune responses and may have a key role in antitumor immunity. T cell metabolism is normally held under tight regulation in an immune response of glycolysis to promote effector T cell expansion and function. However, tumors may deplete nutrients, generate toxic products, or stimulate conserved negative feedback mechanisms, such as through Programmed Cell Death 1 (PD-1), to impair effector T cell nutrient uptake and metabolic fitness. In addition, regulatory T cells are favored in low glucose conditions and may inhibit antitumor immune responses. Here, we review how the tumor microenvironment modifies metabolic and functional pathways in T cells and how these changes may uncover new targets and challenges for cancer immunotherapy and treatment.

Full Text

Duke Authors

Cited Authors

  • Siska, PJ; Rathmell, JC

Published Date

  • April 2015

Published In

Volume / Issue

  • 36 / 4

Start / End Page

  • 257 - 264

PubMed ID

  • 25773310

Pubmed Central ID

  • 25773310

Electronic International Standard Serial Number (EISSN)

  • 1471-4981

Digital Object Identifier (DOI)

  • 10.1016/j.it.2015.02.007


  • eng

Conference Location

  • England