The future of cardiovascular clinical research in North America and beyond-addressing challenges and leveraging opportunities through unique academic and grassroots collaborations.

Journal Article (Journal Article;Review)

Recent developments have highlighted the challenges facing cardiovascular clinical research in global contemporary practice, particularly in North America, including shifting priorities for drug development targets, increasing regulatory requirements, and expensive operational approaches for conducting randomized clinical trials. Nonetheless, emerging trends such as the consolidation of practices and hospitals into integrated health systems, the integration of electronic health records from thousands of practices into large data repositories to support prospective research studies, and streamlined operational approaches such as registry-based trials and risk-based monitoring have created numerous opportunities to disrupt the clinical research paradigm. Within this context, academic research organizations around the globe, particularly a strengthened collaboration of 3 established academic research organizations in North America, are uniquely positioned to promote and develop grassroots collaborations across all types of clinical practices, to delineate successful solutions to obstacles that limit clinical research initiatives, and to guide the future of cardiovascular research in the global research environment.

Full Text

Duke Authors

Cited Authors

  • Roe, MT; Mahaffey, KW; Ezekowitz, JA; Alexander, JH; Goodman, SG; Hernandez, A; Temple, T; Berdan, L; Califf, RM; Harrington, RA; Peterson, ED; Armstrong, PW

Published Date

  • June 2015

Published In

Volume / Issue

  • 169 / 6

Start / End Page

  • 743 - 750

PubMed ID

  • 26027610

Electronic International Standard Serial Number (EISSN)

  • 1097-6744

Digital Object Identifier (DOI)

  • 10.1016/j.ahj.2015.03.002


  • eng

Conference Location

  • United States