Phenolic diterpenoid derivatives as anti-influenza a virus agents.

Journal Article (Journal Article)

A series of diterpenoid derivatives based on podocarpic acid were synthesized and evaluated as anti-influenza A virus agents. Several of the novel podocarpic acid derivatives exhibited nanomolar activities against an H1N1 influenza A virus (A/Puerto Rico/8/34) that was resistant to two anti-influenza drugs, oseltamivir and amantadine. This class of compounds inhibits the influenza virus by targeting the viral hemagglutinin-mediated membrane fusion. These results indicated that podocarpic acid derivatives may serve as potential drug candidates to fight drug-resistant influenza A virus infections.

Full Text

Duke Authors

Cited Authors

  • Dang, Z; Jung, K; Zhu, L; Xie, H; Lee, K-H; Chen, C-H; Huang, L

Published Date

  • March 12, 2015

Published In

Volume / Issue

  • 6 / 3

Start / End Page

  • 355 - 358

PubMed ID

  • 25815159

Pubmed Central ID

  • PMC4360168

International Standard Serial Number (ISSN)

  • 1948-5875

Digital Object Identifier (DOI)

  • 10.1021/ml500533x


  • eng

Conference Location

  • United States