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CASP7 variants modify susceptibility to cervical cancer in Chinese women.

Publication ,  Journal Article
Shi, T-Y; He, J; Wang, M-Y; Zhu, M-L; Yu, K-D; Shao, Z-M; Sun, M-H; Wu, X; Cheng, X; Wei, Q
Published in: Sci Rep
March 18, 2015

Polymorphisms in Caspase-7 (CASP7) may modulate the programmed cell death and thus contribute to cervical cancer risk. In this case-control study of 1,486 cervical cancer cases and 1,301 controls, we investigated associations between four potentially functional polymorphisms in CASP7 and cervical cancer risk and evaluated their locus-locus interaction effects on the risk. The genotype-phenotype correlation was performed by a generalized linear regression model. We found that the rs4353229 polymorphism was associated with cervical cancer risk (under a recessive model: crude OR = 1.20, 95% CI = 1.02-1.40). Compared with the TT genotype, the rs10787498GT genotype was associated with an increased cervical cancer risk (adjusted OR = 1.19, 95% CI = 1.00-1.41). Combination analysis showed that subjects with four putative risk genotypes had a 1.54-fold increased cancer risk, compared with those who carried three or less putative risk genotypes. We also observed significant locus-locus joint effects on the risk, which may be mediated by the polymorphisms regulating CASP7 mRNA expression. Subsequent multifactor dimensionality reduction and classification and regression tree analyses indicated that the CASP7 genotypes might have a locus-locus interaction effect that modulated cervical cancer risk. Out data suggest that CASP7 polymorphisms may interact to modify cervical cancer risk by a possible mechanism of regulating CASP7 mRNA expression.

Duke Scholars

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

March 18, 2015

Volume

5

Start / End Page

9225

Location

England

Related Subject Headings

  • Uterine Cervical Neoplasms
  • RNA, Messenger
  • Polymorphism, Single Nucleotide
  • Odds Ratio
  • Logistic Models
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Genetic Loci
  • Genetic Association Studies
 

Citation

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Shi, T.-Y., He, J., Wang, M.-Y., Zhu, M.-L., Yu, K.-D., Shao, Z.-M., … Wei, Q. (2015). CASP7 variants modify susceptibility to cervical cancer in Chinese women. Sci Rep, 5, 9225. https://doi.org/10.1038/srep09225
Shi, Ting-Yan, Jing He, Meng-Yun Wang, Mei-Ling Zhu, Ke-Da Yu, Zhi-Ming Shao, Meng-Hong Sun, Xiaohua Wu, Xi Cheng, and Qingyi Wei. “CASP7 variants modify susceptibility to cervical cancer in Chinese women.Sci Rep 5 (March 18, 2015): 9225. https://doi.org/10.1038/srep09225.
Shi T-Y, He J, Wang M-Y, Zhu M-L, Yu K-D, Shao Z-M, et al. CASP7 variants modify susceptibility to cervical cancer in Chinese women. Sci Rep. 2015 Mar 18;5:9225.
Shi, Ting-Yan, et al. “CASP7 variants modify susceptibility to cervical cancer in Chinese women.Sci Rep, vol. 5, Mar. 2015, p. 9225. Pubmed, doi:10.1038/srep09225.
Shi T-Y, He J, Wang M-Y, Zhu M-L, Yu K-D, Shao Z-M, Sun M-H, Wu X, Cheng X, Wei Q. CASP7 variants modify susceptibility to cervical cancer in Chinese women. Sci Rep. 2015 Mar 18;5:9225.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

March 18, 2015

Volume

5

Start / End Page

9225

Location

England

Related Subject Headings

  • Uterine Cervical Neoplasms
  • RNA, Messenger
  • Polymorphism, Single Nucleotide
  • Odds Ratio
  • Logistic Models
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Genetic Loci
  • Genetic Association Studies