The gut connectome: making sense of what you eat.

Journal Article (Journal Article)

The enteric nervous system has been studied thus far as an isolated unit. As researchers probe deeper into the function of this system, it is evident that the neural network stretches beyond enteric neurons. It is formed by both intrinsic and extrinsic neurons innervating the gut, enteric glia, and innervated sensory epithelial cells, such as enteroendocrine cells. This Review series summarizes recent knowledge on function and disease of nerves, glia, and sensory epithelial cells of the gut in eight distinctive articles. The timing and growing knowledge for each individual field calls for an appropriate term encompassing the entire system. We call this neuronal ensemble the "gut connectome" and summarize the work from a food sensory perspective.

Full Text

Duke Authors

Cited Authors

  • Bohórquez, DV; Liddle, RA

Published Date

  • March 2, 2015

Published In

Volume / Issue

  • 125 / 3

Start / End Page

  • 888 - 890

PubMed ID

  • 25729849

Pubmed Central ID

  • PMC4382222

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI81121


  • eng

Conference Location

  • United States