HPTN 062: a feasibility and acceptability pilot intervention to reduce HIV transmission risk behaviors among individuals with acute and early HIV infection in Lilongwe, Malawi.

Journal Article (Journal Article)

Acute HIV infection (AHI) is a relatively brief period of time when individuals are highly infectious and the opportunity to intervene to prevent forward transmission is extremely limited. HPTN 062 partnered with CHAVI 001 to evaluate the feasibility and acceptability of a motivational interviewing (MI)-based counseling intervention to reduce HIV-transmission risk behaviors among individuals with acute and early HIV infection in Lilongwe, Malawi. Participants were randomized to receive either (1) brief education sessions about HIV and AHI; or (2) the same brief education sessions plus an MI-based counseling intervention called Uphungu Wanga. Although Uphungu Wanga was determined to be feasible and acceptable, few major differences existed between the two arms with regard to acceptability, feasibility, and self-reported sexual behaviors. We therefore conclude that an additional MI-based counseling intervention may not be needed during the short period of AHI. Instead, we recommend that individuals with AHI receive frequent, but brief, counseling immediately after diagnosis and then transition to receiving counseling at less frequent intervals until they can initiate antiretroviral therapy. Other recommendations are provided.

Full Text

Duke Authors

Cited Authors

  • Corneli, A; Pettifor, A; Kamanga, G; Golin, C; McKenna, K; Ou, S-S; Hamela, G; Massa, C; Martinson, F; Tharaldson, J; Hilgenberg, D; Yu, X; Chege, W; Hoffman, I; HPTN 062 study team,

Published Date

  • September 2014

Published In

Volume / Issue

  • 18 / 9

Start / End Page

  • 1785 - 1800

PubMed ID

  • 24523007

Pubmed Central ID

  • PMC4183128

Electronic International Standard Serial Number (EISSN)

  • 1573-3254

Digital Object Identifier (DOI)

  • 10.1007/s10461-014-0707-1


  • eng

Conference Location

  • United States