Novel therapeutic targets of tumor metabolism.

Published

Journal Article (Review)

The study of tumor metabolism has resulted in new understandings of how cancer cells modify metabolic pathways that control cellular energetics to allow increased proliferation and survival. Tumor cells have been shown to alter metabolic pathways involved in glucose, glutamine, and mitochondrial metabolism to generate raw materials needed for rapid cellular proliferation, maintain favorable cellular redox environments, modify cellular epigenetics, and even promote and maintain oncogenic transformation. As a consequence, there has been intense scientific and clinical interest in targeting metabolic alterations that are commonly adopted by tumor cells for therapeutic purposes. In this review, we describe common metabolic alterations seen in tumor cells and discuss how these alterations are being investigated as potential targets for pharmacological intervention in preclinical and clinical settings. We also discuss some of the challenges associated with using tumor metabolism as a therapeutic target in cancer therapy, along with potential avenues to overcome these challenges.

Full Text

Duke Authors

Cited Authors

  • Kishton, RJ; Rathmell, JC

Published Date

  • March 2015

Published In

Volume / Issue

  • 21 / 2

Start / End Page

  • 62 - 69

PubMed ID

  • 25815845

Pubmed Central ID

  • 25815845

Electronic International Standard Serial Number (EISSN)

  • 1540-336X

Digital Object Identifier (DOI)

  • 10.1097/PPO.0000000000000099

Language

  • eng

Conference Location

  • United States