Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.

Published

Journal Article

Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10(-13)) and corneal curvature (Pmeta=2.9 × 10(-40)) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta=1.13, Pmeta=0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.

Full Text

Duke Authors

Cited Authors

  • Miyake, M; Yamashiro, K; Tabara, Y; Suda, K; Morooka, S; Nakanishi, H; Khor, C-C; Chen, P; Qiao, F; Nakata, I; Akagi-Kurashige, Y; Gotoh, N; Tsujikawa, A; Meguro, A; Kusuhara, S; Polasek, O; Hayward, C; Wright, AF; Campbell, H; Richardson, AJ; Schache, M; Takeuchi, M; Mackey, DA; Hewitt, AW; Cuellar, G; Shi, Y; Huang, L; Yang, Z; Leung, KH; Kao, PYP; Yap, MKH; Yip, SP; Moriyama, M; Ohno-Matsui, K; Mizuki, N; MacGregor, S; Vitart, V; Aung, T; Saw, S-M; Tai, E-S; Wong, TY; Cheng, C-Y; Baird, PN; Yamada, R; Matsuda, F; Nagahama Study Group, ; Yoshimura, N

Published Date

  • March 31, 2015

Published In

Volume / Issue

  • 6 /

Start / End Page

  • 6689 -

PubMed ID

  • 25823570

Pubmed Central ID

  • 25823570

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

International Standard Serial Number (ISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/ncomms7689

Language

  • eng