A common variant near TGFBR3 is associated with primary open angle glaucoma.

Journal Article (Journal Article)

Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10(-33)), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10(-8)). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis.

Full Text

Duke Authors

Cited Authors

  • Li, Z; Allingham, RR; Nakano, M; Jia, L; Chen, Y; Ikeda, Y; Mani, B; Chen, L-J; Kee, C; Garway-Heath, DF; Sripriya, S; Fuse, N; Abu-Amero, KK; Huang, C; Namburi, P; Burdon, K; Perera, SA; Gharahkhani, P; Lin, Y; Ueno, M; Ozaki, M; Mizoguchi, T; Krishnadas, SR; Osman, EA; Lee, MC; Chan, ASY; Tajudin, L-SA; Do, T; Goncalves, A; Reynier, P; Zhang, H; Bourne, R; Goh, D; Broadway, D; Husain, R; Negi, AK; Su, DH; Ho, C-L; Blanco, AA; Leung, CKS; Wong, TT; Yakub, A; Liu, Y; Nongpiur, ME; Han, JC; Hon, DN; Shantha, B; Zhao, B; Sang, J; Zhang, N; Sato, R; Yoshii, K; Panda-Jonas, S; Ashley Koch, AE; Herndon, LW; Moroi, SE; Challa, P; Foo, JN; Bei, J-X; Zeng, Y-X; Simmons, CP; Bich Chau, TN; Sharmila, PF; Chew, M; Lim, B; Tam, POS; Chua, E; Ng, XY; Yong, VHK; Chong, YF; Meah, WY; Vijayan, S; Seongsoo, S; Xu, W; Teo, YY; Cooke Bailey, JN; Kang, JH; Haines, JL; Cheng, CY; Saw, S-M; Tai, E-S; ICAARE-Glaucoma Consortium, ; NEIGHBORHOOD Consortium, ; Richards, JE; Ritch, R; Gaasterland, DE; Pasquale, LR; Liu, J; Jonas, JB; Milea, D; George, R; Al-Obeidan, SA; Mori, K; Macgregor, S; Hewitt, AW; Girkin, CA; Zhang, M; Sundaresan, P; Vijaya, L; Mackey, DA; Wong, TY; Craig, JE; Sun, X; Kinoshita, S; Wiggs, JL; Khor, C-C; Yang, Z; Pang, CP; Wang, N; Hauser, MA; Tashiro, K; Aung, T; Vithana, EN

Published Date

  • July 1, 2015

Published In

Volume / Issue

  • 24 / 13

Start / End Page

  • 3880 - 3892

PubMed ID

  • 25861811

Pubmed Central ID

  • PMC4459396

Electronic International Standard Serial Number (EISSN)

  • 1460-2083

Digital Object Identifier (DOI)

  • 10.1093/hmg/ddv128


  • eng

Conference Location

  • England