Predicting Alzheimer's Disease Using Combined Imaging-Whole Genome SNP Data.

Published

Journal Article

The growing public threat of Alzheimer's disease (AD) has raised the urgency to discover and validate prognostic biomarkers in order to predicting time to onset of AD. It is anticipated that both whole genome single nucleotide polymorphism (SNP) data and high dimensional whole brain imaging data offer predictive values to identify subjects at risk for progressing to AD. The aim of this paper is to test whether both whole genome SNP data and whole brain imaging data offer predictive values to identify subjects at risk for progressing to AD. In 343 subjects with mild cognitive impairment (MCI) enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI-1), we extracted high dimensional MR imaging (volumetric data on 93 brain regions plus a surface fluid registration based hippocampal subregion and surface data), and whole genome data (504,095 SNPs from GWAS), as well as routine neurocognitive and clinical data at baseline. MCI patients were then followed over 48 months, with 150 participants progressing to AD. Combining information from whole brain MR imaging and whole genome data was substantially superior to the standard model for predicting time to onset of AD in a 48-month national study of subjects at risk. Our findings demonstrate the promise of combined imaging-whole genome prognostic markers in people with mild memory impairment.

Full Text

Duke Authors

Cited Authors

  • Kong, D; Giovanello, KS; Wang, Y; Lin, W; Lee, E; Fan, Y; Murali Doraiswamy, P; Zhu, H

Published Date

  • January 2015

Published In

Volume / Issue

  • 46 / 3

Start / End Page

  • 695 - 702

PubMed ID

  • 25869783

Pubmed Central ID

  • 25869783

Electronic International Standard Serial Number (EISSN)

  • 1875-8908

International Standard Serial Number (ISSN)

  • 1387-2877

Digital Object Identifier (DOI)

  • 10.3233/JAD-150164

Language

  • eng