Integrated metabolomics and genomics: systems approaches to biomarkers and mechanisms of cardiovascular disease.

Journal Article (Journal Article;Review)

The genetic architecture underlying the heritability of cardiovascular disease is incompletely understood. Metabolomics is an emerging technology platform that has shown early success in identifying biomarkers and mechanisms of common chronic diseases. Integration of metabolomics, genetics, and other omics platforms in a systems biology approach holds potential for elucidating novel genetic markers and mechanisms for cardiovascular disease. We review important studies that have used metabolomic profiling in cardiometabolic diseases, approaches for integrating metabolomics with genetics and other molecular profiling platforms, and key studies showing the potential for such studies in deciphering cardiovascular disease genetics, biomarkers, and mechanisms.

Full Text

Duke Authors

Cited Authors

  • Shah, SH; Newgard, CB

Published Date

  • April 2015

Published In

Volume / Issue

  • 8 / 2

Start / End Page

  • 410 - 419

PubMed ID

  • 25901039

Pubmed Central ID

  • PMC4408557

Electronic International Standard Serial Number (EISSN)

  • 1942-3268

Digital Object Identifier (DOI)

  • 10.1161/CIRCGENETICS.114.000223


  • eng

Conference Location

  • United States