Analyzing the Impact of Increasing Mechanical Index and Energy Deposition on Shear Wave Speed Reconstruction in Human Liver.

Journal Article (Journal Article)

Shear wave elasticity imaging (SWEI) has found success in liver fibrosis staging. This work evaluates hepatic SWEI measurement success as a function of push pulse energy using two mechanical index (MI) values (1.6 and 2.2) over a range of pulse durations. Shear wave speed (SWS) was measured in the livers of 26 study subjects with known or potential chronic liver diseases. Each measurement consisted of eight SWEI sequences, each with different push energy configurations. The rate of successful SWS estimation was linearly proportional to the push energy. SWEI measurements with higher push energy were successful in patients for whom standard push energy levels failed. The findings also suggest that liver capsule depth could be used prospectively to identify patients who would benefit from elevated output. We conclude that there is clinical benefit to using elevated acoustic output for hepatic SWS measurement in patients with deeper livers.

Full Text

Duke Authors

Cited Authors

  • Deng, Y; Palmeri, ML; Rouze, NC; Rosenzweig, SJ; Abdelmalek, MF; Nightingale, KR

Published Date

  • July 2015

Published In

Volume / Issue

  • 41 / 7

Start / End Page

  • 1948 - 1957

PubMed ID

  • 25896024

Pubmed Central ID

  • PMC4461469

Electronic International Standard Serial Number (EISSN)

  • 1879-291X

International Standard Serial Number (ISSN)

  • 0301-5629

Digital Object Identifier (DOI)

  • 10.1016/j.ultrasmedbio.2015.02.019


  • eng