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Twenty-eight cases of Mycobacterium marinum infection: retrospective case series and literature review.

Publication ,  Journal Article
Johnson, MG; Stout, JE
Published in: Infection
December 2015

PURPOSE: Invasive Mycobacterium marinum disease (tenosynovitis and osteomyelitis) may be an increasingly common manifestation of M. marinum infection that presents unique diagnostic and therapeutic challenges. We conducted a retrospective case series and literature review of M. marinum infection to better understand the clinical spectrum of invasive versus cutaneous disease. METHODS: We reviewed electronic medical records for all M. marinum infections at Duke University Medical Center from January 1, 1996 to April 30, 2014. Published case series of M. marinum infection since 1990 reporting >5 cases were systematically ascertained and reviewed. RESULTS: Twenty-eight cases of M. marinum infection were identified from our institution. Twenty cases (87 %) involved aquatic exposure, and 26 (93 %) involved finger and/or hand lesions. Median time to diagnosis was 3.5 months. Nineteen (68 %) cases had invasive infection, and 9 (32 %) were cutaneous; invasive infection was more common with older age. Granulomatous inflammation and acid-fast bacilli were noted on pathologic examination in 11 (58 %) and 3 (16 %) cases, respectively. Primarily monotherapy was used in 2 (12 %) cases, dual therapy in 8 (47 %) cases, and three-drug therapy in 7 (41 %) cases; three-drug therapy was more common with invasive infection. Median duration of treatment was 5 months. Adjunctive surgery was performed for 18 (95 %) cases of invasive infection and 4 (44 %) of cutaneous infection. Twenty-one (75 %) cases improved, while 7 (25 %) were lost to follow-up. CONCLUSIONS: Distinguishing between invasive and cutaneous M. marinum infection may have important consequences in terms of antibiotic choice and need for adjunctive surgery.

Duke Scholars

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Published In

Infection

DOI

EISSN

1439-0973

Publication Date

December 2015

Volume

43

Issue

6

Start / End Page

655 / 662

Location

Germany

Related Subject Headings

  • Treatment Outcome
  • Tenosynovitis
  • Skin Diseases, Bacterial
  • Retrospective Studies
  • Osteomyelitis
  • North Carolina
  • Mycobacterium marinum
  • Mycobacterium Infections, Nontuberculous
  • Middle Aged
  • Microbiology
 

Citation

APA
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MLA
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Johnson, M. G., & Stout, J. E. (2015). Twenty-eight cases of Mycobacterium marinum infection: retrospective case series and literature review. Infection, 43(6), 655–662. https://doi.org/10.1007/s15010-015-0776-8
Johnson, Matthew G., and Jason E. Stout. “Twenty-eight cases of Mycobacterium marinum infection: retrospective case series and literature review.Infection 43, no. 6 (December 2015): 655–62. https://doi.org/10.1007/s15010-015-0776-8.
Johnson, Matthew G., and Jason E. Stout. “Twenty-eight cases of Mycobacterium marinum infection: retrospective case series and literature review.Infection, vol. 43, no. 6, Dec. 2015, pp. 655–62. Pubmed, doi:10.1007/s15010-015-0776-8.
Journal cover image

Published In

Infection

DOI

EISSN

1439-0973

Publication Date

December 2015

Volume

43

Issue

6

Start / End Page

655 / 662

Location

Germany

Related Subject Headings

  • Treatment Outcome
  • Tenosynovitis
  • Skin Diseases, Bacterial
  • Retrospective Studies
  • Osteomyelitis
  • North Carolina
  • Mycobacterium marinum
  • Mycobacterium Infections, Nontuberculous
  • Middle Aged
  • Microbiology