Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.
Journal Article (Journal Article)
The limited armamentarium of active and oral antifungal drugs against emerging non-Aspergillus molds is of particular concern. Current antifungal agents and the new orally available beta-1,3-d-glucan synthase inhibitor SCY-078 were tested in vitro against 135 clinical non-Aspergillus mold isolates. Akin to echinocandins, SCY-078 showed no or poor activity against Mucoromycotina and Fusarium spp. However, SCY-078 was highly active against Paecilomyces variotii and was the only compound displaying some activity against notoriously panresistant Scedosporium prolificans.
Full Text
Duke Authors
Cited Authors
- Lamoth, F; Alexander, BD
Published Date
- July 2015
Published In
Volume / Issue
- 59 / 7
Start / End Page
- 4308 - 4311
PubMed ID
- 25896696
Pubmed Central ID
- PMC4468689
Electronic International Standard Serial Number (EISSN)
- 1098-6596
Digital Object Identifier (DOI)
- 10.1128/AAC.00234-15
Language
- eng
Conference Location
- United States