Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.

Journal Article (Journal Article)

The limited armamentarium of active and oral antifungal drugs against emerging non-Aspergillus molds is of particular concern. Current antifungal agents and the new orally available beta-1,3-d-glucan synthase inhibitor SCY-078 were tested in vitro against 135 clinical non-Aspergillus mold isolates. Akin to echinocandins, SCY-078 showed no or poor activity against Mucoromycotina and Fusarium spp. However, SCY-078 was highly active against Paecilomyces variotii and was the only compound displaying some activity against notoriously panresistant Scedosporium prolificans.

Full Text

Duke Authors

Cited Authors

  • Lamoth, F; Alexander, BD

Published Date

  • July 2015

Published In

Volume / Issue

  • 59 / 7

Start / End Page

  • 4308 - 4311

PubMed ID

  • 25896696

Pubmed Central ID

  • PMC4468689

Electronic International Standard Serial Number (EISSN)

  • 1098-6596

Digital Object Identifier (DOI)

  • 10.1128/AAC.00234-15

Language

  • eng

Conference Location

  • United States