Phenotype standardization for statin-induced myotoxicity

Journal Article (Review;Journal)

Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.

Full Text

Duke Authors

Cited Authors

  • Alfirevic, A; Neely, D; Armitage, J; Chinoy, H; Cooper, RG; Laaksonen, R; Carr, DF; Bloch, KM; Fahy, J; Hanson, A; Yue, QY; Wadelius, M; Maitland-Van Der Zee, AH; Voora, D; Psaty, BM; Palmer, CNA; Pirmohamed, M

Published Date

  • October 1, 2014

Published In

Volume / Issue

  • 96 / 4

Start / End Page

  • 470 - 476

Electronic International Standard Serial Number (EISSN)

  • 1532-6535

International Standard Serial Number (ISSN)

  • 0009-9236

Digital Object Identifier (DOI)

  • 10.1038/clpt.2014.121

Citation Source

  • Scopus