High-sensitivity rod photoreceptor input to the blue-yellow color opponent pathway in macaque retina.

Journal Article (Journal Article)

Small bistratified cells (SBCs) in the primate retina carry a major blue-yellow opponent signal to the brain. We found that SBCs also carry signals from rod photoreceptors, with the same sign as S cone input. SBCs exhibited robust responses under low scotopic conditions. Physiological and anatomical experiments indicated that this rod input arose from the AII amacrine cell-mediated rod pathway. Rod and cone signals were both present in SBCs at mesopic light levels. These findings have three implications. First, more retinal circuits may multiplex rod and cone signals than were previously thought to, efficiently exploiting the limited number of optic nerve fibers. Second, signals from AII amacrine cells may diverge to most or all of the approximately 20 retinal ganglion cell types in the peripheral primate retina. Third, rod input to SBCs may be the substrate for behavioral biases toward perception of blue at mesopic light levels.

Full Text

Duke Authors

Cited Authors

  • Field, GD; Greschner, M; Gauthier, JL; Rangel, C; Shlens, J; Sher, A; Marshak, DW; Litke, AM; Chichilnisky, EJ

Published Date

  • September 2009

Published In

Volume / Issue

  • 12 / 9

Start / End Page

  • 1159 - 1164

PubMed ID

  • 19668201

Pubmed Central ID

  • PMC2789108

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

Digital Object Identifier (DOI)

  • 10.1038/nn.2353


  • eng

Conference Location

  • United States