Viruses and the DNA Damage Response: Activation and Antagonism.

Published

Journal Article

Viruses must interact with their hosts in order to replicate; these interactions often provoke the evolutionarily conserved response to DNA damage, known as the DNA damage response (DDR). The DDR can be activated by incoming viral DNA, during the integration of retroviruses, or in response to the aberrant DNA structures generated upon replication of DNA viruses. Furthermore, DNA and RNA viral proteins can induce the DDR by promoting inappropriate S phase entry, by modifying cellular DDR factors directly, or by unintentionally targeting host DNA. The DDR may be antiviral, although viruses often require proximal DDR activation of repair and recombination factors to facilitate replication as well as downstream DDR signaling suppression to ensure cell survival. An unintended consequence of DDR attenuation during infection is the long-term survival and proliferation of precancerous cells. Therefore, the molecular basis for DDR activation and attenuation by viruses remains an important area of study that will likely provide key insights into how viruses have evolved with their hosts.

Full Text

Duke Authors

Cited Authors

  • Luftig, MA

Published Date

  • November 2014

Published In

Volume / Issue

  • 1 / 1

Start / End Page

  • 605 - 625

PubMed ID

  • 26958736

Pubmed Central ID

  • 26958736

International Standard Serial Number (ISSN)

  • 2327-056X

Digital Object Identifier (DOI)

  • 10.1146/annurev-virology-031413-085548

Language

  • eng

Conference Location

  • United States