Spinal cord stimulation alleviates motor deficits in a primate model of Parkinson disease.

Published

Journal Article

Although deep brain electrical stimulation can alleviate the motor symptoms of Parkinson disease (PD), just a small fraction of patients with PD can take advantage of this procedure due to its invasive nature. A significantly less invasive method--epidural spinal cord stimulation (SCS)--has been suggested as an alternative approach for symptomatic treatment of PD. However, the mechanisms underlying motor improvements through SCS are unknown. Here, we show that SCS reproducibly alleviates motor deficits in a primate model of PD. Simultaneous neuronal recordings from multiple structures of the cortico-basal ganglia-thalamic loop in parkinsonian monkeys revealed abnormal highly synchronized neuronal activity within each of these structures and excessive functional coupling among them. SCS disrupted this pathological circuit behavior in a manner that mimics the effects caused by pharmacological dopamine replacement therapy or deep brain stimulation. These results suggest that SCS should be considered as an additional treatment option for patients with PD.

Full Text

Duke Authors

Cited Authors

  • Santana, MB; Halje, P; Simplício, H; Richter, U; Freire, MAM; Petersson, P; Fuentes, R; Nicolelis, MAL

Published Date

  • November 19, 2014

Published In

Volume / Issue

  • 84 / 4

Start / End Page

  • 716 - 722

PubMed ID

  • 25447740

Pubmed Central ID

  • 25447740

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2014.08.061

Language

  • eng

Conference Location

  • United States