Adaptation of pandemic H2N2 influenza A viruses in humans.


Journal Article

The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we performed analyses on genetic sequences of 175 newly sequenced human and avian H2N2 virus isolates and all publicly available influenza virus genomes.

Full Text

Cited Authors

  • Joseph, U; Linster, M; Suzuki, Y; Krauss, S; Halpin, RA; Vijaykrishna, D; Fabrizio, TP; Bestebroer, TM; Maurer-Stroh, S; Webby, RJ; Wentworth, DE; Fouchier, RAM; Bahl, J; Smith, GJD; CEIRS H2N2 Working Group,

Published Date

  • February 2015

Published In

Volume / Issue

  • 89 / 4

Start / End Page

  • 2442 - 2447

PubMed ID

  • 25505070

Pubmed Central ID

  • 25505070

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/JVI.02590-14


  • eng