Perioperative cognitive decline in the aging population.

Journal Article (Journal Article)

Elderly patients who have an acute illness or who undergo surgery often experience cognitive decline. The pathophysiologic mechanisms that cause neurodegeneration resulting in cognitive decline, including protein deposition and neuroinflammation, also play a role in animal models of surgery-induced cognitive decline. With the aging of the population, surgical candidates of advanced age with underlying neurodegeneration are encountered more often, raising concerns that, in patients with this combination, cognitive function will precipitously decline postoperatively. This special article is based on a symposium that the University of California, San Francisco, convened to explore the contributions of surgery and anesthesia to the development of cognitive decline in the aged patient. A road map to further elucidate the mechanisms, diagnosis, risk factors, mitigation, and treatment of postoperative cognitive decline in the elderly is provided.

Full Text

Duke Authors

Cited Authors

  • Terrando, N; Brzezinski, M; Degos, V; Eriksson, LI; Kramer, JH; Leung, JM; Miller, BL; Seeley, WW; Vacas, S; Weiner, MW; Yaffe, K; Young, WL; Xie, Z; Maze, M

Published Date

  • September 2011

Published In

Volume / Issue

  • 86 / 9

Start / End Page

  • 885 - 893

PubMed ID

  • 21878601

Pubmed Central ID

  • PMC3257991

Electronic International Standard Serial Number (EISSN)

  • 1942-5546

Digital Object Identifier (DOI)

  • 10.4065/mcp.2011.0332


  • eng

Conference Location

  • England