Fibrosis in nonalcoholic Fatty liver disease: mechanisms and clinical implications.


Journal Article (Review)

Nonalcoholic fatty liver disease (NAFLD) is tightly associated with obesity and the metabolic syndrome in the United States and other Western countries. It is also the liver disease most rapidly increasing in prevalence in the United States, and has become a major indication for liver transplantation worldwide. Compelling evidence shows that the degree of liver fibrosis dictates liver prognosis in NAFLD. This review focuses on fibrosis based on clinical and basic perspectives. The authors summarize the physiopathology of fibrosis development and progression in NAFLD, highlighting its molecular mechanisms, clinical consequences of fibrosis, the diagnostic approach and management strategies.

Full Text

Duke Authors

Cited Authors

  • Angulo, P; Machado, MV; Diehl, AM

Published Date

  • May 2015

Published In

Volume / Issue

  • 35 / 2

Start / End Page

  • 132 - 145

PubMed ID

  • 25974899

Pubmed Central ID

  • 25974899

Electronic International Standard Serial Number (EISSN)

  • 1098-8971

Digital Object Identifier (DOI)

  • 10.1055/s-0035-1550065


  • eng

Conference Location

  • United States