Hyperpolarized Gas MR Imaging: Technique and Applications.

Journal Article (Journal Article;Review)

Functional imaging offers information more sensitive to changes in lung structure and function. Hyperpolarized helium ((3)He) and xenon ((129)Xe) MR imaging of the lungs provides sensitive contrast mechanisms to probe changes in pulmonary ventilation, microstructure, and gas exchange. Gas imaging has shifted to the use of (129)Xe. Xenon is well-tolerated. (129)Xe is soluble in pulmonary tissue, which allows exploring specific lung function characteristics involved in gas exchange and alveolar oxygenation. Hyperpolarized gases and (129)Xe in particular stand to be an excellent probe of pulmonary structure and function, and provide sensitive and noninvasive biomarkers for pulmonary diseases.

Full Text

Duke Authors

Cited Authors

  • Roos, JE; McAdams, HP; Kaushik, SS; Driehuys, B

Published Date

  • May 2015

Published In

Volume / Issue

  • 23 / 2

Start / End Page

  • 217 - 229

PubMed ID

  • 25952516

Pubmed Central ID

  • PMC4428591

Electronic International Standard Serial Number (EISSN)

  • 1557-9786

Digital Object Identifier (DOI)

  • 10.1016/j.mric.2015.01.003


  • eng

Conference Location

  • United States