Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI.

Journal Article (Journal Article)

PURPOSE: The aim of this study was to evaluate the effect of hyperpolarized (129)Xe dose on image signal-to-noise ratio (SNR) and ventilation defect conspicuity on both multi-slice gradient echo and isotropic 3D-radially acquired ventilation MRI. MATERIALS AND METHODS: Ten non-smoking older subjects (ages 60.8±7.9years) underwent hyperpolarized (HP) (129)Xe ventilation MRI using both GRE and 3D-radial acquisitions, each tested using a 71ml (high) and 24ml (low) dose equivalent (DE) of fully polarized, fully enriched (129)Xe. For all images SNR and ventilation defect percentage (VDP) were calculated. RESULTS: Normalized SNR (SNRn), obtained by dividing SNR by voxel volume and dose was higher for high-DE GRE acquisitions (SNRn=1.9±0.8ml(-2)) than low-DE GRE scans (SNRn=0.8±0.2ml(-2)). Radially acquired images exhibited a more consistent, albeit lower SNRn (High-DE: SNRn=0.5±0.1ml(-2), low-DE: SNRn=0.5±0.2ml(-2)). VDP was indistinguishable across all scans. CONCLUSIONS: These results suggest that images acquired using the high-DE GRE sequence provided the highest SNRn, which was in agreement with previous reports in the literature. 3D-radial images had lower SNRn, but have advantages for visual display, monitoring magnetization dynamics, and visualizing physiological gradients. By evaluating normalized SNR in the context of dose-equivalent formalism, it should be possible to predict (129)Xe dose requirements and quantify the benefits of more efficient transmit/receive coils, field strengths, and pulse sequences.

Full Text

Duke Authors

Cited Authors

  • He, M; Robertson, SH; Kaushik, SS; Freeman, MS; Virgincar, RS; Davies, J; Stiles, J; Foster, WM; McAdams, HP; Driehuys, B

Published Date

  • September 2015

Published In

Volume / Issue

  • 33 / 7

Start / End Page

  • 877 - 885

PubMed ID

  • 25936684

Pubmed Central ID

  • PMC4466055

Electronic International Standard Serial Number (EISSN)

  • 1873-5894

Digital Object Identifier (DOI)

  • 10.1016/j.mri.2015.04.005


  • eng

Conference Location

  • Netherlands