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Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI.

Publication ,  Journal Article
He, M; Robertson, SH; Kaushik, SS; Freeman, MS; Virgincar, RS; Davies, J; Stiles, J; Foster, WM; McAdams, HP; Driehuys, B
Published in: Magn Reson Imaging
September 2015

PURPOSE: The aim of this study was to evaluate the effect of hyperpolarized (129)Xe dose on image signal-to-noise ratio (SNR) and ventilation defect conspicuity on both multi-slice gradient echo and isotropic 3D-radially acquired ventilation MRI. MATERIALS AND METHODS: Ten non-smoking older subjects (ages 60.8±7.9years) underwent hyperpolarized (HP) (129)Xe ventilation MRI using both GRE and 3D-radial acquisitions, each tested using a 71ml (high) and 24ml (low) dose equivalent (DE) of fully polarized, fully enriched (129)Xe. For all images SNR and ventilation defect percentage (VDP) were calculated. RESULTS: Normalized SNR (SNRn), obtained by dividing SNR by voxel volume and dose was higher for high-DE GRE acquisitions (SNRn=1.9±0.8ml(-2)) than low-DE GRE scans (SNRn=0.8±0.2ml(-2)). Radially acquired images exhibited a more consistent, albeit lower SNRn (High-DE: SNRn=0.5±0.1ml(-2), low-DE: SNRn=0.5±0.2ml(-2)). VDP was indistinguishable across all scans. CONCLUSIONS: These results suggest that images acquired using the high-DE GRE sequence provided the highest SNRn, which was in agreement with previous reports in the literature. 3D-radial images had lower SNRn, but have advantages for visual display, monitoring magnetization dynamics, and visualizing physiological gradients. By evaluating normalized SNR in the context of dose-equivalent formalism, it should be possible to predict (129)Xe dose requirements and quantify the benefits of more efficient transmit/receive coils, field strengths, and pulse sequences.

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Published In

Magn Reson Imaging

DOI

EISSN

1873-5894

Publication Date

September 2015

Volume

33

Issue

7

Start / End Page

877 / 885

Location

Netherlands

Related Subject Headings

  • Xenon Isotopes
  • Ultrasonography
  • Signal-To-Noise Ratio
  • Signal Processing, Computer-Assisted
  • Sensitivity and Specificity
  • Respiration Disorders
  • Reproducibility of Results
  • Pulmonary Ventilation
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
 

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He, M., Robertson, S. H., Kaushik, S. S., Freeman, M. S., Virgincar, R. S., Davies, J., … Driehuys, B. (2015). Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI. Magn Reson Imaging, 33(7), 877–885. https://doi.org/10.1016/j.mri.2015.04.005
He, Mu, Scott H. Robertson, S Sivaram Kaushik, Matthew S. Freeman, Rohan S. Virgincar, John Davies, Jane Stiles, William M. Foster, H Page McAdams, and Bastiaan Driehuys. “Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI.Magn Reson Imaging 33, no. 7 (September 2015): 877–85. https://doi.org/10.1016/j.mri.2015.04.005.
He M, Robertson SH, Kaushik SS, Freeman MS, Virgincar RS, Davies J, et al. Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI. Magn Reson Imaging. 2015 Sep;33(7):877–85.
He, Mu, et al. “Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI.Magn Reson Imaging, vol. 33, no. 7, Sept. 2015, pp. 877–85. Pubmed, doi:10.1016/j.mri.2015.04.005.
He M, Robertson SH, Kaushik SS, Freeman MS, Virgincar RS, Davies J, Stiles J, Foster WM, McAdams HP, Driehuys B. Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI. Magn Reson Imaging. 2015 Sep;33(7):877–885.
Journal cover image

Published In

Magn Reson Imaging

DOI

EISSN

1873-5894

Publication Date

September 2015

Volume

33

Issue

7

Start / End Page

877 / 885

Location

Netherlands

Related Subject Headings

  • Xenon Isotopes
  • Ultrasonography
  • Signal-To-Noise Ratio
  • Signal Processing, Computer-Assisted
  • Sensitivity and Specificity
  • Respiration Disorders
  • Reproducibility of Results
  • Pulmonary Ventilation
  • Nuclear Medicine & Medical Imaging
  • Middle Aged