Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI.


Journal Article

The aim of this study was to evaluate the effect of hyperpolarized (129)Xe dose on image signal-to-noise ratio (SNR) and ventilation defect conspicuity on both multi-slice gradient echo and isotropic 3D-radially acquired ventilation MRI.Ten non-smoking older subjects (ages 60.8±7.9years) underwent hyperpolarized (HP) (129)Xe ventilation MRI using both GRE and 3D-radial acquisitions, each tested using a 71ml (high) and 24ml (low) dose equivalent (DE) of fully polarized, fully enriched (129)Xe. For all images SNR and ventilation defect percentage (VDP) were calculated.Normalized SNR (SNRn), obtained by dividing SNR by voxel volume and dose was higher for high-DE GRE acquisitions (SNRn=1.9±0.8ml(-2)) than low-DE GRE scans (SNRn=0.8±0.2ml(-2)). Radially acquired images exhibited a more consistent, albeit lower SNRn (High-DE: SNRn=0.5±0.1ml(-2), low-DE: SNRn=0.5±0.2ml(-2)). VDP was indistinguishable across all scans.These results suggest that images acquired using the high-DE GRE sequence provided the highest SNRn, which was in agreement with previous reports in the literature. 3D-radial images had lower SNRn, but have advantages for visual display, monitoring magnetization dynamics, and visualizing physiological gradients. By evaluating normalized SNR in the context of dose-equivalent formalism, it should be possible to predict (129)Xe dose requirements and quantify the benefits of more efficient transmit/receive coils, field strengths, and pulse sequences.

Full Text

Duke Authors

Cited Authors

  • He, M; Robertson, SH; Kaushik, SS; Freeman, MS; Virgincar, RS; Davies, J; Stiles, J; Foster, WM; McAdams, HP; Driehuys, B

Published Date

  • September 2015

Published In

Volume / Issue

  • 33 / 7

Start / End Page

  • 877 - 885

PubMed ID

  • 25936684

Pubmed Central ID

  • 25936684

Electronic International Standard Serial Number (EISSN)

  • 1873-5894

International Standard Serial Number (ISSN)

  • 0730-725X

Digital Object Identifier (DOI)

  • 10.1016/j.mri.2015.04.005


  • eng