Pain, PSA flare, and bone scan response in a patient with metastatic castration-resistant prostate cancer treated with radium-223, a case report.
Journal Article (Journal Article)
BACKGROUND: Radium-223 has been shown to improve overall survival in men with metastatic castration-resistant prostate cancer with symptomatic bone metastases. The bone scan response to radium-223 has only been described in one single center trial of 14 patients, none of whom achieved the outstanding bone scan response presented in the current case. CASE PRESENTATION: In this case report, we describe a 75 year-old white man with extensively pre-treated metastatic castration-resistant prostate cancer and symptomatic bone metastases who experienced a flare in pain and prostate-specific antigen, followed by dramatic clinical (pain), biochemical (prostate-specific antigen), and imaging (bone scan) response. CONCLUSION: The flare phenomena and bone scan response we observed have not previously been described with radium-223. This case suggests that the degree and duration of bone scan response may be predictive of overall survival benefit.
Full Text
Duke Authors
Cited Authors
- McNamara, MA; George, DJ
Published Date
- May 7, 2015
Published In
Volume / Issue
- 15 /
Start / End Page
- 371 -
PubMed ID
- 25948240
Pubmed Central ID
- PMC4426169
Electronic International Standard Serial Number (EISSN)
- 1471-2407
Digital Object Identifier (DOI)
- 10.1186/s12885-015-1390-y
Language
- eng
Conference Location
- England