Pain, PSA flare, and bone scan response in a patient with metastatic castration-resistant prostate cancer treated with radium-223, a case report.

Journal Article (Journal Article)

BACKGROUND: Radium-223 has been shown to improve overall survival in men with metastatic castration-resistant prostate cancer with symptomatic bone metastases. The bone scan response to radium-223 has only been described in one single center trial of 14 patients, none of whom achieved the outstanding bone scan response presented in the current case. CASE PRESENTATION: In this case report, we describe a 75 year-old white man with extensively pre-treated metastatic castration-resistant prostate cancer and symptomatic bone metastases who experienced a flare in pain and prostate-specific antigen, followed by dramatic clinical (pain), biochemical (prostate-specific antigen), and imaging (bone scan) response. CONCLUSION: The flare phenomena and bone scan response we observed have not previously been described with radium-223. This case suggests that the degree and duration of bone scan response may be predictive of overall survival benefit.

Full Text

Duke Authors

Cited Authors

  • McNamara, MA; George, DJ

Published Date

  • May 7, 2015

Published In

Volume / Issue

  • 15 /

Start / End Page

  • 371 -

PubMed ID

  • 25948240

Pubmed Central ID

  • PMC4426169

Electronic International Standard Serial Number (EISSN)

  • 1471-2407

Digital Object Identifier (DOI)

  • 10.1186/s12885-015-1390-y


  • eng

Conference Location

  • England