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Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin.

Publication ,  Journal Article
Baht, GS; Silkstone, D; Vi, L; Nadesan, P; Amani, Y; Whetstone, H; Wei, Q; Alman, BA
Published in: Nat Commun
May 19, 2015

The capacity for tissues to repair and regenerate diminishes with age. We sought to determine the age-dependent contribution of native mesenchymal cells and circulating factors on in vivo bone repair. Here we show that exposure to youthful circulation by heterochronic parabiosis reverses the aged fracture repair phenotype and the diminished osteoblastic differentiation capacity of old animals. This rejuvenation effect is recapitulated by engraftment of young haematopoietic cells into old animals. During rejuvenation, β-catenin signalling, a pathway important in osteoblast differentiation, is modulated in the early repair process and required for rejuvenation of the aged phenotype. Temporal reduction of β-catenin signalling during early fracture repair improves bone healing in old mice. Our data indicate that young haematopoietic cells have the capacity to rejuvenate bone repair and this is mediated at least in part through β-catenin, raising the possibility that agents that modulate β-catenin can improve the pace or quality of fracture repair in the ageing population.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

May 19, 2015

Volume

6

Start / End Page

7131

Location

England

Related Subject Headings

  • beta Catenin
  • Wnt Proteins
  • Time Factors
  • Tibia
  • Signal Transduction
  • Regeneration
  • Phenotype
  • Parabiosis
  • Osteogenesis
  • Osteoblasts
 

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Baht, G. S., Silkstone, D., Vi, L., Nadesan, P., Amani, Y., Whetstone, H., … Alman, B. A. (2015). Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin. Nat Commun, 6, 7131. https://doi.org/10.1038/ncomms8131
Baht, Gurpreet S., David Silkstone, Linda Vi, Puviindran Nadesan, Yasha Amani, Heather Whetstone, Qingxia Wei, and Benjamin A. Alman. “Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin.Nat Commun 6 (May 19, 2015): 7131. https://doi.org/10.1038/ncomms8131.
Baht GS, Silkstone D, Vi L, Nadesan P, Amani Y, Whetstone H, et al. Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin. Nat Commun. 2015 May 19;6:7131.
Baht, Gurpreet S., et al. “Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin.Nat Commun, vol. 6, May 2015, p. 7131. Pubmed, doi:10.1038/ncomms8131.
Baht GS, Silkstone D, Vi L, Nadesan P, Amani Y, Whetstone H, Wei Q, Alman BA. Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin. Nat Commun. 2015 May 19;6:7131.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

May 19, 2015

Volume

6

Start / End Page

7131

Location

England

Related Subject Headings

  • beta Catenin
  • Wnt Proteins
  • Time Factors
  • Tibia
  • Signal Transduction
  • Regeneration
  • Phenotype
  • Parabiosis
  • Osteogenesis
  • Osteoblasts