Vaginal drug distribution modeling.

Published

Journal Article (Review)

This review presents and applies fundamental mass transport theory describing the diffusion and convection driven mass transport of drugs to the vaginal environment. It considers sources of variability in the predictions of the models. It illustrates use of model predictions of microbicide drug concentration distribution (pharmacokinetics) to gain insights about drug effectiveness in preventing HIV infection (pharmacodynamics). The modeling compares vaginal drug distributions after different gel dosage regimens, and it evaluates consequences of changes in gel viscosity due to aging. It compares vaginal mucosal concentration distributions of drugs delivered by gels vs. intravaginal rings. Finally, the modeling approach is used to compare vaginal drug distributions across species with differing vaginal dimensions. Deterministic models of drug mass transport into and throughout the vaginal environment can provide critical insights about the mechanisms and determinants of such transport. This knowledge, and the methodology that obtains it, can be applied and translated to multiple applications, involving the scientific underpinnings of vaginal drug distribution and the performance evaluation and design of products, and their dosage regimens, that achieve it.

Full Text

Duke Authors

Cited Authors

  • Katz, DF; Yuan, A; Gao, Y

Published Date

  • September 2015

Published In

Volume / Issue

  • 92 /

Start / End Page

  • 2 - 13

PubMed ID

  • 25933938

Pubmed Central ID

  • 25933938

Electronic International Standard Serial Number (EISSN)

  • 1872-8294

International Standard Serial Number (ISSN)

  • 0169-409X

Digital Object Identifier (DOI)

  • 10.1016/j.addr.2015.04.017

Language

  • eng