Skip to main content
Journal cover image

Functional optical coherence tomography: principles and progress.

Publication ,  Journal Article
Kim, J; Brown, W; Maher, JR; Levinson, H; Wax, A
Published in: Phys Med Biol
May 21, 2015

In the past decade, several functional extensions of optical coherence tomography (OCT) have emerged, and this review highlights key advances in instrumentation, theoretical analysis, signal processing and clinical application of these extensions. We review five principal extensions: Doppler OCT (DOCT), polarization-sensitive OCT (PS-OCT), optical coherence elastography (OCE), spectroscopic OCT (SOCT), and molecular imaging OCT. The former three have been further developed with studies in both ex vivo and in vivo human tissues. This review emphasizes the newer techniques of SOCT and molecular imaging OCT, which show excellent potential for clinical application but have yet to be well reviewed in the literature. SOCT elucidates tissue characteristics, such as oxygenation and carcinogenesis, by detecting wavelength-dependent absorption and scattering of light in tissues. While SOCT measures endogenous biochemical distributions, molecular imaging OCT detects exogenous molecular contrast agents. These newer advances in functional OCT broaden the potential clinical application of OCT by providing novel ways to understand tissue activity that cannot be accomplished by other current imaging methodologies.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

May 21, 2015

Volume

60

Issue

10

Start / End Page

R211 / R237

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Signal Processing, Computer-Assisted
  • Nuclear Medicine & Medical Imaging
  • Contrast Media
  • 5105 Medical and biological physics
  • 1103 Clinical Sciences
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kim, J., Brown, W., Maher, J. R., Levinson, H., & Wax, A. (2015). Functional optical coherence tomography: principles and progress. Phys Med Biol, 60(10), R211–R237. https://doi.org/10.1088/0031-9155/60/10/R211
Kim, Jina, William Brown, Jason R. Maher, Howard Levinson, and Adam Wax. “Functional optical coherence tomography: principles and progress.Phys Med Biol 60, no. 10 (May 21, 2015): R211–37. https://doi.org/10.1088/0031-9155/60/10/R211.
Kim J, Brown W, Maher JR, Levinson H, Wax A. Functional optical coherence tomography: principles and progress. Phys Med Biol. 2015 May 21;60(10):R211–37.
Kim, Jina, et al. “Functional optical coherence tomography: principles and progress.Phys Med Biol, vol. 60, no. 10, May 2015, pp. R211–37. Pubmed, doi:10.1088/0031-9155/60/10/R211.
Kim J, Brown W, Maher JR, Levinson H, Wax A. Functional optical coherence tomography: principles and progress. Phys Med Biol. 2015 May 21;60(10):R211–R237.
Journal cover image

Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

May 21, 2015

Volume

60

Issue

10

Start / End Page

R211 / R237

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Signal Processing, Computer-Assisted
  • Nuclear Medicine & Medical Imaging
  • Contrast Media
  • 5105 Medical and biological physics
  • 1103 Clinical Sciences
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences