Functional optical coherence tomography: principles and progress.

Journal Article (Journal Article;Review)

In the past decade, several functional extensions of optical coherence tomography (OCT) have emerged, and this review highlights key advances in instrumentation, theoretical analysis, signal processing and clinical application of these extensions. We review five principal extensions: Doppler OCT (DOCT), polarization-sensitive OCT (PS-OCT), optical coherence elastography (OCE), spectroscopic OCT (SOCT), and molecular imaging OCT. The former three have been further developed with studies in both ex vivo and in vivo human tissues. This review emphasizes the newer techniques of SOCT and molecular imaging OCT, which show excellent potential for clinical application but have yet to be well reviewed in the literature. SOCT elucidates tissue characteristics, such as oxygenation and carcinogenesis, by detecting wavelength-dependent absorption and scattering of light in tissues. While SOCT measures endogenous biochemical distributions, molecular imaging OCT detects exogenous molecular contrast agents. These newer advances in functional OCT broaden the potential clinical application of OCT by providing novel ways to understand tissue activity that cannot be accomplished by other current imaging methodologies.

Full Text

Duke Authors

Cited Authors

  • Kim, J; Brown, W; Maher, JR; Levinson, H; Wax, A

Published Date

  • May 21, 2015

Published In

Volume / Issue

  • 60 / 10

Start / End Page

  • R211 - R237

PubMed ID

  • 25951836

Pubmed Central ID

  • PMC4448140

Electronic International Standard Serial Number (EISSN)

  • 1361-6560

Digital Object Identifier (DOI)

  • 10.1088/0031-9155/60/10/R211


  • eng

Conference Location

  • England