Human olfactory receptor responses to odorants.

Journal Article (Journal Article)

Although the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by olfactory receptors. In large part this is due to a paucity of data in a search space covering the interactions of hundreds of receptors with billions of odorous molecules. Of the approximately 400 intact human odorant receptors, only 10% have a published ligand. Here we used a heterologous luciferase assay to screen 73 odorants against a clone library of 511 human olfactory receptors. This dataset will allow other researchers to interrogate the combinatorial nature of olfactory coding.

Full Text

Duke Authors

Cited Authors

  • Mainland, JD; Li, YR; Zhou, T; Liu, WLL; Matsunami, H

Published Date

  • 2015

Published In

Volume / Issue

  • 2 /

Start / End Page

  • 150002 -

PubMed ID

  • 25977809

Pubmed Central ID

  • PMC4412152

International Standard Serial Number (ISSN)

  • 2052-4463

Digital Object Identifier (DOI)

  • 10.1038/sdata.2015.2


  • eng

Conference Location

  • England