Human olfactory receptor responses to odorants.
Journal Article (Journal Article)
Although the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by olfactory receptors. In large part this is due to a paucity of data in a search space covering the interactions of hundreds of receptors with billions of odorous molecules. Of the approximately 400 intact human odorant receptors, only 10% have a published ligand. Here we used a heterologous luciferase assay to screen 73 odorants against a clone library of 511 human olfactory receptors. This dataset will allow other researchers to interrogate the combinatorial nature of olfactory coding.
- Mainland, JD; Li, YR; Zhou, T; Liu, WLL; Matsunami, H
Volume / Issue
- 2 /
Start / End Page
- 150002 -
Pubmed Central ID
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)