Periodontal disease in patients with chronic coronary heart disease: Prevalence and association with cardiovascular risk factors.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

AIM: There are reported links between periodontal disease (PD) and cardiovascular (CV) risk but data are lacking, especially from populations with established coronary heart disease (CHD). This study describes self-reported indicators of PD and associations with CV risk factors in a global stable CHD population. METHODS AND RESULTS: A total of 15,828 participants in the global STABILITY trial underwent a physical examination, blood sampling, and completed a lifestyle questionnaire. They reported remaining number of teeth (none, 1-14, 15-20, 21-25 or 26-32 (all)) and frequency of gum bleeding (never/rarely, sometimes, often or always). Adjusted linear and logistic regression models assessed associations between tooth loss, gum bleeding, and socioeconomic and CV risk factors. A total of 40.9% of participants had <15 remaining teeth; 16.4% had no teeth; and 25.6% reported gum bleeding with large differences in prevalence among countries, regions and ethnic groups. Less tooth loss was associated with lower levels of glucose, low-density lipoprotein (LDL) cholesterol, systolic blood pressure, waist circumference and hs-CRP; higher estimated glomerular filtration rate; decreased odds for diabetes and smoking, and increased odds for higher education, alcohol consumption and work stress. Gum bleeding was associated with higher LDL cholesterol and systolic blood pressure; decreased odds for smoking, but increased odds for higher education, alcohol consumption and stress. CONCLUSION: Self-reported indicators of PD were common in this chronic CHD population and were associated with an increasing socioeconomic and CV risk factor burden. However, causality between self-reported PD and CV risk and outcome needs further investigation.

Full Text

Duke Authors

Cited Authors

  • Vedin, O; Hagström, E; Gallup, D; Neely, ML; Stewart, R; Koenig, W; Budaj, A; Sritara, P; Wallentin, L; White, HD; Held, C

Published Date

  • June 2015

Published In

Volume / Issue

  • 22 / 6

Start / End Page

  • 771 - 778

PubMed ID

  • 24721691

Electronic International Standard Serial Number (EISSN)

  • 2047-4881

Digital Object Identifier (DOI)

  • 10.1177/2047487314530660


  • eng

Conference Location

  • England