Patient-reported medication adherence barriers among patients with cardiovascular risk factors.

Journal Article (Journal Article)

BACKGROUND: Many patients experience barriers that make it difficult to take cardiovascular disease (CVD)-related medications as prescribed. The Cardiovascular Intervention Improvement Telemedicine Study (CITIES) was a tailored behavioral pharmacist-administered and telephone-based intervention for reducing CVD risk. OBJECTIVES: To (a) describe patient-reported barriers to taking their medication as prescribed and (b) evaluate patient-level characteristics associated with reporting medication barriers. METHODS: We recruited patients receiving care at primary care clinics affiliated with Durham Veterans Affairs Medical Center. Eligible patients were diagnosed with hypertension and/or hyperlipidemia that were poorly controlled (blood pressure of > 150/100 mmHg and/or low-density lipoprotein value > 130 mg/dL). At the time of enrollment, patients completed an interview with 7 questions derived from a validated medication barriers measure. Patient characteristics and individual medication treatment barriers are described. Multivariable linear regression was used to examine the association between a medication barrier score and patient characteristics. RESULTS: Most patients (n = 428) were married or living with their partners (57%) and were men (85%) who were diagnosed with hypertension and hyperlipidemia (64%). The most commonly reported barriers were having too much medication to take (31%) and forgetting whether medication was taken at a particular time (24%). In adjusted analysis, those who were not employed (1.32, 95% CI = 0.50-2.14) or did not have someone to help with tasks, if needed (1.66, 95% CI = 0.42-2.89), reported higher medication barrier scores. Compared with those diagnosed with hypertension and hyperlipidemia, those with only hypertension (0.91, 95% CI = 0.04-1.79) reported higher medication barrier scores. CONCLUSIONS: Barriers to medication adherence are common. Evaluating and addressing barriers may increase medication adherence.

Full Text

Duke Authors

Cited Authors

  • Zullig, LL; Stechuchak, KM; Goldstein, KM; Olsen, MK; McCant, FM; Danus, S; Crowley, MJ; Oddone, EZ; Bosworth, HB

Published Date

  • June 2015

Published In

Volume / Issue

  • 21 / 6

Start / End Page

  • 479 - 485

PubMed ID

  • 26011549

Electronic International Standard Serial Number (EISSN)

  • 2376-1032

Digital Object Identifier (DOI)

  • 10.18553/jmcp.2015.21.6.479


  • eng

Conference Location

  • United States