miR-23a blockade enhances adoptive T cell transfer therapy by preserving immune-competence in the tumor microenvironment.

Journal Article (Journal Article)

In adoptive T cell transfer therapy (ACT), the antitumor efficacy of cytotoxic CD8+ T lymphocytes (CTLs) has been limited by tumor-induced immunosuppression. We have demonstrated that miR-23a blockade in tumor-specific CTLs conferred resilience to TGFβ-mediated immunosuppression, resulting in superior tumor control. Our studies highlight miR-23a in tumor-specific CTLs as a clinically relevant target to enhance ACT.

Full Text

Duke Authors

Cited Authors

  • Lin, R; Sampson, JH; Li, Q-J; Zhu, B

Published Date

  • March 2015

Published In

Volume / Issue

  • 4 / 3

Start / End Page

  • e990803 -

PubMed ID

  • 25949909

Pubmed Central ID

  • PMC4404905

International Standard Serial Number (ISSN)

  • 2162-4011

Digital Object Identifier (DOI)

  • 10.4161/2162402X.2014.990803


  • eng

Conference Location

  • United States