miR-23a blockade enhances adoptive T cell transfer therapy by preserving immune-competence in the tumor microenvironment.
In adoptive T cell transfer therapy (ACT), the antitumor efficacy of cytotoxic CD8+ T lymphocytes (CTLs) has been limited by tumor-induced immunosuppression. We have demonstrated that miR-23a blockade in tumor-specific CTLs conferred resilience to TGFβ-mediated immunosuppression, resulting in superior tumor control. Our studies highlight miR-23a in tumor-specific CTLs as a clinically relevant target to enhance ACT.
Lin, R; Sampson, JH; Li, Q-J; Zhu, B
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