miR-23a blockade enhances adoptive T cell transfer therapy by preserving immune-competence in the tumor microenvironment.
Publication
, Journal Article
Lin, R; Sampson, JH; Li, Q-J; Zhu, B
Published in: Oncoimmunology
March 2015
In adoptive T cell transfer therapy (ACT), the antitumor efficacy of cytotoxic CD8+ T lymphocytes (CTLs) has been limited by tumor-induced immunosuppression. We have demonstrated that miR-23a blockade in tumor-specific CTLs conferred resilience to TGFβ-mediated immunosuppression, resulting in superior tumor control. Our studies highlight miR-23a in tumor-specific CTLs as a clinically relevant target to enhance ACT.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Oncoimmunology
DOI
ISSN
2162-4011
Publication Date
March 2015
Volume
4
Issue
3
Start / End Page
e990803
Location
United States
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 3204 Immunology
- 1112 Oncology and Carcinogenesis
- 1107 Immunology
Citation
APA
Chicago
ICMJE
MLA
NLM
Lin, R., Sampson, J. H., Li, Q.-J., & Zhu, B. (2015). miR-23a blockade enhances adoptive T cell transfer therapy by preserving immune-competence in the tumor microenvironment. Oncoimmunology, 4(3), e990803. https://doi.org/10.4161/2162402X.2014.990803
Lin, Regina, John H. Sampson, Qi-Jing Li, and Bo Zhu. “miR-23a blockade enhances adoptive T cell transfer therapy by preserving immune-competence in the tumor microenvironment.” Oncoimmunology 4, no. 3 (March 2015): e990803. https://doi.org/10.4161/2162402X.2014.990803.
Lin R, Sampson JH, Li Q-J, Zhu B. miR-23a blockade enhances adoptive T cell transfer therapy by preserving immune-competence in the tumor microenvironment. Oncoimmunology. 2015 Mar;4(3):e990803.
Lin, Regina, et al. “miR-23a blockade enhances adoptive T cell transfer therapy by preserving immune-competence in the tumor microenvironment.” Oncoimmunology, vol. 4, no. 3, Mar. 2015, p. e990803. Pubmed, doi:10.4161/2162402X.2014.990803.
Lin R, Sampson JH, Li Q-J, Zhu B. miR-23a blockade enhances adoptive T cell transfer therapy by preserving immune-competence in the tumor microenvironment. Oncoimmunology. 2015 Mar;4(3):e990803.
Published In
Oncoimmunology
DOI
ISSN
2162-4011
Publication Date
March 2015
Volume
4
Issue
3
Start / End Page
e990803
Location
United States
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 3204 Immunology
- 1112 Oncology and Carcinogenesis
- 1107 Immunology