Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature.

Journal Article (Journal Article;Review)

UNLABELLED: Avascular necrosis (AVN) occurs in several chronic illnesses, including systemic lupus erythematosus (SLE), but can also occur in healthy children. There are multiple theories to explain why and how AVN occurs, but an exact mechanism has yet to be unraveled. AVN in the pediatric lupus population is understudied. The Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, provides an excellent venue to conduct an exploratory analysis to assess associations between AVN and demographics, SLE disease activity and vitamin D deficiency. Herein we present a brief report describing our findings, as well as reviewing the literature on AVN in SLE and other entities. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00065806.

Full Text

Duke Authors

Cited Authors

  • Gurion, R; Tangpricha, V; Yow, E; Schanberg, LE; McComsey, GA; Robinson, AB; Atherosclerosis Prevention in Pediatric Lupus Erythematosus Investigators,

Published Date

  • April 23, 2015

Published In

Volume / Issue

  • 13 /

Start / End Page

  • 13 -

PubMed ID

  • 25902709

Pubmed Central ID

  • PMC4415214

Electronic International Standard Serial Number (EISSN)

  • 1546-0096

Digital Object Identifier (DOI)

  • 10.1186/s12969-015-0008-x


  • eng

Conference Location

  • England