An active role for basement membrane assembly and modification in tissue sculpting.


Journal Article (Review)

Basement membranes are a dense, sheet-like form of extracellular matrix (ECM) that underlie epithelia and endothelia, and surround muscle, fat and Schwann cells. Basement membranes separate tissues and protect them from mechanical stress. Although traditionally thought of as a static support structure, a growing body of evidence suggests that dynamic basement membrane deposition and modification instructs coordinated cellular behaviors and acts mechanically to sculpt tissues. In this Commentary, we highlight recent studies that support the idea that far from being a passive matrix, basement membranes play formative roles in shaping tissues.

Full Text

Duke Authors

Cited Authors

  • Morrissey, MA; Sherwood, DR

Published Date

  • May 2015

Published In

Volume / Issue

  • 128 / 9

Start / End Page

  • 1661 - 1668

PubMed ID

  • 25717004

Pubmed Central ID

  • 25717004

Electronic International Standard Serial Number (EISSN)

  • 1477-9137

International Standard Serial Number (ISSN)

  • 0021-9533

Digital Object Identifier (DOI)

  • 10.1242/jcs.168021


  • eng