The lung is protected from spontaneous inflammation by autophagy in myeloid cells.
Journal Article (Journal Article)
The lung is constantly exposed to the outer environment; thus, it must maintain a state of immune ignorance or tolerance not to overrespond to harmless environmental stimuli. How cells in the lung control immune responses under nonpathogenic condition is not fully understood. In this study, we found that autophagy plays a critical role in the lung-specific immune regulation that prevents spontaneous inflammation. Autophagy in pulmonary myeloid cells plays a role in maintaining low burdens of environmental microbes in the lung, as well as in lowering mitochondrial reactive oxygen species production and preventing overresponse to TLR4 ligands in alveolar macrophages. Based on these mechanisms, we also found that intranasal instillation of antibiotics or an inhibitor of reactive oxygen species was efficient in preventing spontaneous pulmonary inflammation. Thus, autophagy in myeloid cells, particularly alveolar macrophages, is critical for inhibiting spontaneous pulmonary inflammation, and pulmonary inflammation caused by dysfunctional autophagy is pharmacologically prevented.
Full Text
Duke Authors
Cited Authors
- Kanayama, M; He, Y-W; Shinohara, ML
Published Date
- June 1, 2015
Published In
Volume / Issue
- 194 / 11
Start / End Page
- 5465 - 5471
PubMed ID
- 25911758
Pubmed Central ID
- PMC4433845
Electronic International Standard Serial Number (EISSN)
- 1550-6606
Digital Object Identifier (DOI)
- 10.4049/jimmunol.1403249
Language
- eng
Conference Location
- United States