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Host-Directed Therapies for Tuberculosis.

Publication ,  Journal Article
Tobin, DM
Published in: Cold Spring Harb Perspect Med
May 18, 2015

Host-directed therapies are a relatively new and promising approach to treatment of tuberculosis. Modulation of specific host immune pathways, including those that impact inflammation and immunopathology, can limit mycobacterial infection and pathology, both in cell culture and in animal models. This review explores a range of host pathways and drugs, some already approved for clinical use that have the potential to provide new adjunctive therapies for tuberculosis. Drugs targeting host processes may largely avoid the development of bacterial antibiotic resistance, a major public health concern for tuberculosis. However, these drugs may also have generally increased risk for side effects on the host. Understanding the specific mechanisms by which these drugs act and the relationship of these mechanisms to Mycobacterium tuberculosis pathogenesis will be critical in selecting appropriate host-directed therapy. Overall, these host-directed compounds provide a novel strategy for antituberculosis therapy.

Duke Scholars

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Published In

Cold Spring Harb Perspect Med

DOI

EISSN

2157-1422

Publication Date

May 18, 2015

Volume

5

Issue

10

Location

United States

Related Subject Headings

  • Vitamin D
  • Tuberculosis
  • Protein Kinases
  • Phosphodiesterase Inhibitors
  • Neutrophils
  • Mycobacterium tuberculosis
  • Matrix Metalloproteinases
  • Lipid Metabolism
  • Inflammation
  • Immunotherapy
 

Citation

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Tobin, D. M. (2015). Host-Directed Therapies for Tuberculosis. Cold Spring Harb Perspect Med, 5(10). https://doi.org/10.1101/cshperspect.a021196
Tobin, David M. “Host-Directed Therapies for Tuberculosis.Cold Spring Harb Perspect Med 5, no. 10 (May 18, 2015). https://doi.org/10.1101/cshperspect.a021196.
Tobin DM. Host-Directed Therapies for Tuberculosis. Cold Spring Harb Perspect Med. 2015 May 18;5(10).
Tobin, David M. “Host-Directed Therapies for Tuberculosis.Cold Spring Harb Perspect Med, vol. 5, no. 10, May 2015. Pubmed, doi:10.1101/cshperspect.a021196.
Tobin DM. Host-Directed Therapies for Tuberculosis. Cold Spring Harb Perspect Med. 2015 May 18;5(10).

Published In

Cold Spring Harb Perspect Med

DOI

EISSN

2157-1422

Publication Date

May 18, 2015

Volume

5

Issue

10

Location

United States

Related Subject Headings

  • Vitamin D
  • Tuberculosis
  • Protein Kinases
  • Phosphodiesterase Inhibitors
  • Neutrophils
  • Mycobacterium tuberculosis
  • Matrix Metalloproteinases
  • Lipid Metabolism
  • Inflammation
  • Immunotherapy