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The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial.

Publication ,  Journal Article
Chandrasiri, UP; Fowkes, FJI; Richards, JS; Langer, C; Fan, Y-M; Taylor, SM; Beeson, JG; Dewey, KG; Maleta, K; Ashorn, P; Rogerson, SJ
Published in: Malar J
May 10, 2015

BACKGROUND: Malaria and undernutrition frequently coexist, especially in pregnant women and young children. Nutrient supplementation of these vulnerable groups might reduce their susceptibility to malaria by improving immunity. METHODS: Antibody immunity to antigens expressed by a placental-binding parasite isolate, a non-placental binding parasite isolate, merozoites and schizonts at enrolment (before 20 gestation weeks) and at 36 gestation weeks were measured in 1,009 Malawian pregnant women receiving a daily lipid-based nutrient supplement, multiple micronutrients or iron and folic acid, who were participants in a randomized clinical trial assessing the effects of nutrient supplementation on pregnancy outcomes and child development (registration ID: NCT01239693). RESULTS: Antibodies to placental-binding isolates significantly increased while antibodies to most merozoite antigens declined over pregnancy. Overall, after adjustment for covariates, the type of supplementation did not influence antibody levels at 36 gestation weeks or the rate of change in antibody levels from enrolment to 36 weeks. A negative association between maternal body mass index and opsonizing antibodies to placental-binding antigens (coefficient (95% CI) -1.04 (-1.84, -0.24), was observed. Similarly, women with higher socioeconomic status had significantly lower IgG and opsonizing antibodies to placental-binding antigens. Neither of these associations was significantly influenced by the supplementation type. CONCLUSIONS: In the current cohort nutrient supplementation did not affect anti-malarial antibody responses, but poor and undernourished mothers should be a priority group in future trials.

Duke Scholars

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Published In

Malar J

DOI

EISSN

1475-2875

Publication Date

May 10, 2015

Volume

14

Start / End Page

193

Location

England

Related Subject Headings

  • Young Adult
  • Tropical Medicine
  • Schizonts
  • Pregnancy Outcome
  • Pregnancy
  • Plasmodium
  • Micronutrients
  • Merozoites
  • Malawi
  • Malaria
 

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Chandrasiri, U. P., Fowkes, F. J. I., Richards, J. S., Langer, C., Fan, Y.-M., Taylor, S. M., … Rogerson, S. J. (2015). The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial. Malar J, 14, 193. https://doi.org/10.1186/s12936-015-0707-2
Chandrasiri, Upeksha P., Freya J. I. Fowkes, Jack S. Richards, Christine Langer, Yue-Mei Fan, Steve M. Taylor, James G. Beeson, et al. “The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial.Malar J 14 (May 10, 2015): 193. https://doi.org/10.1186/s12936-015-0707-2.
Chandrasiri UP, Fowkes FJI, Richards JS, Langer C, Fan Y-M, Taylor SM, et al. The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial. Malar J. 2015 May 10;14:193.
Chandrasiri, Upeksha P., et al. “The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial.Malar J, vol. 14, May 2015, p. 193. Pubmed, doi:10.1186/s12936-015-0707-2.
Chandrasiri UP, Fowkes FJI, Richards JS, Langer C, Fan Y-M, Taylor SM, Beeson JG, Dewey KG, Maleta K, Ashorn P, Rogerson SJ. The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial. Malar J. 2015 May 10;14:193.
Journal cover image

Published In

Malar J

DOI

EISSN

1475-2875

Publication Date

May 10, 2015

Volume

14

Start / End Page

193

Location

England

Related Subject Headings

  • Young Adult
  • Tropical Medicine
  • Schizonts
  • Pregnancy Outcome
  • Pregnancy
  • Plasmodium
  • Micronutrients
  • Merozoites
  • Malawi
  • Malaria