Optically modulated cancer therapeutic delivery: past, present and future.

Journal Article (Review;Journal Article)

Chemotherapeutic regimens are often restricted by dose-limiting toxicities that arise from drug exposure to off-site tissues. Nanoparticle drug carriers that specifically deliver therapeutics to the site of malignant tissue are being actively researched today. One strategy is to utilize materials that are light-responsive, such that the carrier can be triggered to release its drug payload at the distinct time and location of light exposure. This review discusses recent advances in the development of such light-responsive drug carriers. With continued optimization and in vivo validation, these approaches may offer novel treatment options for cancer management.

Full Text

Duke Authors

Cited Authors

  • Strong, LE; West, JL

Published Date

  • January 2015

Published In

Volume / Issue

  • 6 / 5

Start / End Page

  • 545 - 558

PubMed ID

  • 26001172

Electronic International Standard Serial Number (EISSN)

  • 2041-6008

International Standard Serial Number (ISSN)

  • 2041-5990

Digital Object Identifier (DOI)

  • 10.4155/tde.15.17


  • eng