Point of care and factor concentrate-based coagulation algorithms.


Other Article (Review)

In the last years it has become evident that the use of blood products should be reduced whenever possible. There is increasing evidence regarding serious adverse events, including higher mortality and morbidity, related to transfusions. The use of point of care (POC) devices integrated in algorithms is one of the important mechanisms to limit blood product exposure. Any type of algorithm, especially the POC-based ones, allows goal-directed transfusions of blood products and even better targeted factor concentrate substitutions. Different types of algorithms in different surgical settings (cardiac surgery, trauma, liver surgery etc.) have been established with growing interest in their use as they offer objective therapy for management and reduction of blood product use. The use of POC devices with evidence-based algorithms is important in the bleeding patient independent of its origin (traumatic vs. surgical). The use of factor concentrates compared to the classical blood products can be cost-saving, beneficial for the patient, and in agreement with the WHO-requested standard of care. The empiric and uncontrolled use of blood products such as fresh frozen plasma, red blood cells, and platelets without POC monitoring should no longer be followed with regard to actual evidence in literature. Furthermore, the use of factor concentrates may provide better outcomes and potential for cost saving.

Full Text

Duke Authors

Cited Authors

  • Theusinger, OM; Stein, P; Levy, JH

Published Date

  • March 2015

Published In

Volume / Issue

  • 42 / 2

Start / End Page

  • 115 - 121

PubMed ID

  • 26019707

Pubmed Central ID

  • 26019707

International Standard Serial Number (ISSN)

  • 1660-3796

Digital Object Identifier (DOI)

  • 10.1159/000381320


  • eng

Conference Location

  • Switzerland