Prospective study of depression among dialysis patients in Saudi Arabia.

Journal Article (Journal Article)

OBJECTIVES: The purpose was to determine the short-term course of depression among dialysis patients in Saudi Arabia and identify baseline characteristics that may influence course. METHODS: Thirty-nine dialysis patients in Jeddah, SA, were identified with subthreshold, minor, or major depressive disorders using the Structured Clinical Interview for Depression (SCID) and followed up at 6 and 12 weeks using the Longitudinal Interview and Follow-up Evaluation (LIFE) schedule. Depressive symptoms were tracked using the Hamilton Depression Rating Scale (HDRS). Patient characteristics measured at baseline included demographic, psychosocial, physical health, and treatment factors. RESULTS: Of the 20 patients with major or minor depressive disorder, eight (40 %) fully remitted by 6 weeks and an additional three patients remitted over the next 6 weeks, leaving 45 % with significant depressive symptoms persisting beyond 12 weeks. Subthreshold disorders followed a similar course (42 % with persistent symptoms). Few patients received treatment for depression. Those with more education, severe health problems, poorer psychological function, more severe depressive symptoms, or a family psychiatric history were less likely to remit. Similar factors predicted change in depressive symptoms assessed by HDRS, especially high medical co-morbidity, severe illness, and overall poor psychological functioning. CONCLUSIONS: Nearly one-half of depressed dialysis patients in Saudi Arabia continue to have significant symptoms beyond 12 weeks of follow-up, few of whom were treated. Specific characteristics at baseline identify depressed dialysis patients at greater risk of persistent symptoms who need treatment.

Full Text

Duke Authors

Cited Authors

  • Al Zaben, F; Sehlo, MG; Khalifa, DA; Al Shohaib, S; Shaheen, F; Alzaben, L; Ahmad, RG; Ashy, JA; Felemban, RG; Koenig, HG

Published Date

  • June 2015

Published In

Volume / Issue

  • 47 / 6

Start / End Page

  • 1001 - 1010

PubMed ID

  • 25899766

Electronic International Standard Serial Number (EISSN)

  • 1573-2584

Digital Object Identifier (DOI)

  • 10.1007/s11255-015-0977-1


  • eng

Conference Location

  • Netherlands