Non-linear dynamics of cardiac alternans: subcellular to tissue-level mechanisms of arrhythmia.

Journal Article (Journal Article)

Cardiac repolarization alternans is a rhythm disturbance of the heart in which rapid stimulation elicits a beat-to-beat alternation in the duration of action potentials and magnitude of intracellular calcium transients in individual cardiac myocytes. Although this phenomenon has been identified as a potential precursor to dangerous reentrant arrhythmias and sudden cardiac death, significant uncertainty remains regarding its mechanism and no clinically practical means of halting its occurrence or progression currently exists. Cardiac alternans has well-characterized tissue, cellular, and subcellular manifestations, the mechanisms and interplay of which are an active area of research.

Full Text

Duke Authors

Cited Authors

  • Gaeta, SA; Christini, DJ

Published Date

  • 2012

Published In

Volume / Issue

  • 3 /

Start / End Page

  • 157 -

PubMed ID

  • 22783195

Pubmed Central ID

  • PMC3389489

Electronic International Standard Serial Number (EISSN)

  • 1664-042X

Digital Object Identifier (DOI)

  • 10.3389/fphys.2012.00157


  • eng

Conference Location

  • Switzerland