New developments in the management of severe skin and deep skin structure infections - focus on tedizolid.

Journal Article (Review)

Tedizolid, a novel oxazolidinone, is approved for treatment of acute bacterial skin and skin structure infections (ABSSSIs). Tedizolid offers several potential advantages over current ABSSSI treatment options. First, tedizolid has a prolonged half-life, which allows for once-daily dosing. Second, tedizolid has broad spectrum activity against Gram-positive organisms including methicillin-resistant Staphylococcus aureus, coagulase-negative staphylococci, and enterococci. Third, tedizolid, available in both intravenous and oral formulations, has high oral bioavailability, allowing for easy oral step-down therapy. Fourth, in patients who have been prescribed selective serotonin reuptake inhibitors or monoamine oxidase inhibitors, tedizolid may have fewer drug interactions than linezolid. Finally, tedizolid may have fewer or comparatively delayed onset side effects than linezolid, including thrombocytopenia and nausea. This review covers the microbiology, pharmacology, mode of action, and pharmacokinetics of tedizolid as well as patient-focused perspectives such as quality of life, patient satisfaction/acceptability, adherence, and uptake and provides expert opinion on the current use of tedizolid for ABSSSIs and potential future therapeutic applications.

Full Text

Duke Authors

Cited Authors

  • Durkin, MJ; Corey, GR

Published Date

  • January 2015

Published In

Volume / Issue

  • 11 /

Start / End Page

  • 857 - 862

PubMed ID

  • 26045667

Electronic International Standard Serial Number (EISSN)

  • 1178-203X

International Standard Serial Number (ISSN)

  • 1176-6336

Digital Object Identifier (DOI)

  • 10.2147/tcrm.s64553

Language

  • eng