Designing synthetic vaccines for HIV.

Journal Article (Review)

Despite three decades of intensive research efforts, the development of an effective prophylactic vaccine against HIV remains an unrealized goal in the global campaign to contain the HIV/AIDS pandemic. Recent characterization of novel epitopes for inducing broadly neutralizing antibodies has fueled research in the design and synthesis of new, well-defined antigenic constructs for the development of HIV envelope-directed vaccines. The present review will cover previous and recent efforts toward the design of synthetic vaccines based on the HIV viral envelope glycoproteins, with special emphasis on examples from our own laboratories. The biological evaluation of some of the most representative vaccine candidates, in terms of their antigenicity and immunogenicity, will also be discussed to illustrate the current state-of-the-art toward the development of fully synthetic HIV vaccines.

Full Text

Duke Authors

Cited Authors

  • Fernández-Tejada, A; Haynes, BF; Danishefsky, SJ

Published Date

  • June 2015

Published In

Volume / Issue

  • 14 / 6

Start / End Page

  • 815 - 831

PubMed ID

  • 25824661

Electronic International Standard Serial Number (EISSN)

  • 1744-8395

International Standard Serial Number (ISSN)

  • 1476-0584

Digital Object Identifier (DOI)

  • 10.1586/14760584.2015.1027690

Language

  • eng