A niche role for cancer exosomes in metastasis.

Journal Article (Journal Article)

Cancer cells are known to secrete exosomes with pro-metastatic effects. Pancreatic-cancer-derived exosomes are now shown to promote liver metastasis by eliciting pre-metastatic niche formation through a multi-step process. This involves uptake of exosome-derived factors by liver Kupffer cells and hepatic stellate cell activation to generate a fibrotic microenvironment with immune cell infiltrates that favours metastasis.

Full Text

Duke Authors

Cited Authors

  • Zhang, Y; Wang, X-F

Published Date

  • June 2015

Published In

Volume / Issue

  • 17 / 6

Start / End Page

  • 709 - 711

PubMed ID

  • 26022917

Electronic International Standard Serial Number (EISSN)

  • 1476-4679

Digital Object Identifier (DOI)

  • 10.1038/ncb3181


  • eng

Conference Location

  • England