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E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program.

Publication ,  Journal Article
Jiang, X; Nevins, JR; Shats, I; Chi, J-T
Published in: PLoS One
2015

The E2F1 transcription factor regulates cell proliferation and apoptosis through the control of a considerable variety of target genes. Previous work has detailed the role of other transcription factors in mediating the specificity of E2F function. Here we identify the NF-YB transcription factor as a novel direct E2F1 target. Genome-wide expression analysis of the effects of NFYB knockdown on E2F1-mediated transcription identified a large group of genes that are co-regulated by E2F1 and NFYB. We also provide evidence that knockdown of NFYB enhances E2F1-induced apoptosis, suggesting a pro-survival function of the NFYB/E2F1 joint transcriptional program. Bioinformatic analysis suggests that deregulation of these NFY-dependent E2F1 target genes might play a role in sarcomagenesis as well as drug resistance.

Duke Scholars

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2015

Volume

10

Issue

6

Start / End Page

e0127951

Location

United States

Related Subject Headings

  • Up-Regulation
  • Transcriptional Activation
  • Transcription, Genetic
  • Sarcoma
  • Humans
  • General Science & Technology
  • Gene Expression Regulation, Neoplastic
  • Gene Expression Profiling
  • E2F1 Transcription Factor
  • Drug Resistance, Neoplasm
 

Citation

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Jiang, X., Nevins, J. R., Shats, I., & Chi, J.-T. (2015). E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program. PLoS One, 10(6), e0127951. https://doi.org/10.1371/journal.pone.0127951
Jiang, Xiaolei, Joseph Roy Nevins, Igor Shats, and Jen-Tsan Chi. “E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program.PLoS One 10, no. 6 (2015): e0127951. https://doi.org/10.1371/journal.pone.0127951.
Jiang, Xiaolei, et al. “E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program.PLoS One, vol. 10, no. 6, 2015, p. e0127951. Pubmed, doi:10.1371/journal.pone.0127951.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2015

Volume

10

Issue

6

Start / End Page

e0127951

Location

United States

Related Subject Headings

  • Up-Regulation
  • Transcriptional Activation
  • Transcription, Genetic
  • Sarcoma
  • Humans
  • General Science & Technology
  • Gene Expression Regulation, Neoplastic
  • Gene Expression Profiling
  • E2F1 Transcription Factor
  • Drug Resistance, Neoplasm