Light Transmission Aggregometry


Book Section

© 2014 by John Wiley & Sons, Ltd. All rights reserved. Laboratory evaluation of platelet function by a simple and reliable in vitro method is crucial to understand the critical role of platelets during hemostasis and thrombotic complications of cardiovascular disease. An in vitro quantitative determination of platelet aggregation by the light transmittance aggregometry (LTA) and the important role of adenosine diphosphate (ADP) during platelet aggregation were first described by Born. Despite its limitations, LTA is still considered as the "gold standard assay" for platelet function measurement. In addition to the assessment of antiplatelet drug response, LTA is also used to study bleeding disorders and congenital or acquired disorders of platelet receptors.

Full Text

Duke Authors

Cited Authors

  • Gurbel, PA; Gesheff, M; Bliden, KP; Tantry, US

Published Date

  • June 3, 2014

Book Title

  • Antiplatelet Therapy in Cardiovascular Disease

Start / End Page

  • 51 - 57

International Standard Book Number 13 (ISBN-13)

  • 9781118275757

Digital Object Identifier (DOI)

  • 10.1002/9781118493984.ch7

Citation Source

  • Scopus