Interleukin-21: a multifunctional regulator of immunity to infections.
Journal Article (Journal Article;Review)
Interleukin-21 (IL-21) is a cytokine that has broad effects on both innate and adaptive immune responses. The roles of IL-21 in determining immunity to infections are currently being defined, and notably, it has been shown that IL-21 is most critical for sustaining T cell responses during chronic viral infections. This article discusses our current understanding of the immunobiology of IL-21, as well as its known and potential roles in influencing immunity to infections.
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Duke Authors
Cited Authors
- Yi, JS; Cox, MA; Zajac, AJ
Published Date
- December 2010
Published In
Volume / Issue
- 12 / 14-15
Start / End Page
- 1111 - 1119
PubMed ID
- 20817119
Pubmed Central ID
- PMC2998550
Electronic International Standard Serial Number (EISSN)
- 1769-714X
Digital Object Identifier (DOI)
- 10.1016/j.micinf.2010.08.008
Language
- eng
Conference Location
- France