Interleukin-21: a multifunctional regulator of immunity to infections.

Journal Article (Journal Article;Review)

Interleukin-21 (IL-21) is a cytokine that has broad effects on both innate and adaptive immune responses. The roles of IL-21 in determining immunity to infections are currently being defined, and notably, it has been shown that IL-21 is most critical for sustaining T cell responses during chronic viral infections. This article discusses our current understanding of the immunobiology of IL-21, as well as its known and potential roles in influencing immunity to infections.

Full Text

Duke Authors

Cited Authors

  • Yi, JS; Cox, MA; Zajac, AJ

Published Date

  • December 2010

Published In

Volume / Issue

  • 12 / 14-15

Start / End Page

  • 1111 - 1119

PubMed ID

  • 20817119

Pubmed Central ID

  • PMC2998550

Electronic International Standard Serial Number (EISSN)

  • 1769-714X

Digital Object Identifier (DOI)

  • 10.1016/j.micinf.2010.08.008


  • eng

Conference Location

  • France