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The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review.

Publication ,  Journal Article
Lazarides, AL; Eward, WC; Speicher, PJ; Hou, C-H; Nussbaum, DP; Green, C; Blazer, DG; Kirsch, DG; Brigman, BE
Published in: Sarcoma
2015

Objective. This study investigated patterns of utilization of radiation therapy (RT) and correlated this with overall survival by assessing patients with well-differentiated soft tissue sarcoma of the extremity (STS-E) in the National Cancer Database (NCDB). Methods. All patients diagnosed with well-differentiated STS-E between 1998 and 2006 were identified in the NCDB. Patients were stratified by use of surgery alone versus use of adjuvant RT after surgery and analyzed using multivariate analysis, Kaplan-Meier analysis, and propensity matching. Results. 2113 patients with well-differentiated STS-E were identified in the NCDB for inclusion with a mean follow-up time of 74 months. 69% of patients were treated with surgery alone, while 26% were treated with surgery followed by adjuvant RT. Patients undergoing amputation were less likely to receive adjuvant RT. There was no difference in overall survival between patients with well-differentiated STS treated with surgery alone and those patients who received adjuvant RT. Conclusions. In the United States, adjuvant RT is being utilized in a quarter of patients being treated for well-differentiated STS-E. While the use of adjuvant RT may be viewed as a means to facilitate limb salvage, this large national database review confirms no survival benefit, regardless of tumor size or margin status.

Duke Scholars

Published In

Sarcoma

DOI

ISSN

1357-714X

Publication Date

2015

Volume

2015

Start / End Page

186581

Location

Egypt

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3203 Dentistry
  • 3202 Clinical sciences
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Lazarides, A. L., Eward, W. C., Speicher, P. J., Hou, C.-H., Nussbaum, D. P., Green, C., … Brigman, B. E. (2015). The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review. Sarcoma, 2015, 186581. https://doi.org/10.1155/2015/186581
Lazarides, Alexander L., William C. Eward, Paul J. Speicher, Chun-Han Hou, Daniel P. Nussbaum, Cindy Green, Dan G. Blazer, David G. Kirsch, and Brian E. Brigman. “The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review.Sarcoma 2015 (2015): 186581. https://doi.org/10.1155/2015/186581.
Lazarides AL, Eward WC, Speicher PJ, Hou C-H, Nussbaum DP, Green C, et al. The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review. Sarcoma. 2015;2015:186581.
Lazarides, Alexander L., et al. “The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review.Sarcoma, vol. 2015, 2015, p. 186581. Pubmed, doi:10.1155/2015/186581.
Lazarides AL, Eward WC, Speicher PJ, Hou C-H, Nussbaum DP, Green C, Blazer DG, Kirsch DG, Brigman BE. The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review. Sarcoma. 2015;2015:186581.
Journal cover image

Published In

Sarcoma

DOI

ISSN

1357-714X

Publication Date

2015

Volume

2015

Start / End Page

186581

Location

Egypt

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3203 Dentistry
  • 3202 Clinical sciences
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences